NOF CORPORATION

Polysorbate and Solubilizer

Polysorbate 80 (HX) (NOFABLE® ESO-9920)

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Application

　IV formulation (Injection)

NOFABLE® ESO-9920 (Polysorbate 80) has outstanding quality below compared with current injectable grade of Polysorbate 80. NOFABLE® ESO-9920 (Polysorbate 80) gives the best result for IV formulation and will be a grobal standard for injectable grade.

  • Low allergic reaction
  • Increased concentration against drug
  • Low toxicity
  • Low peroxide


　Improvement of Analysis

Due to its colorless characteristics, NOFABLE® ESO-9920 (Polysorbate 80) can be provided the best analytical performance than ever. There is less interference UV region at UV spectrum measurement. Since conventional Polysorbate 80 contains many impurities and different fatty acid residues, there are some interferences of desired peak of drug at HPLC analysis. Ultra pure Polysorbate 80 can improve analytical performance at HPLC analysis.


　For Stable Formulation

Polysorbate 80 is frequently used for pharmaceutical formulations as an emulsifier, solubilizer and stabilizer. Improving its characteristics (color, odor, oxidation stability, cytotoxicity and hemolysis) by ultra-purity Polysorbate 80 (NOFABLE® ESO-9920) is very suitable for pharmaceutical application. NOF has more stable and versatile formulation technology for pharmaceuticals, emulsification, and solubilization using our high-purity oleic acid derivatives, include this NOFABLE® ESO-9920, shown as a water/oil/water emulsion in below.

graph
W/O/W emulsion using Ultra pure Polysorbate 80 (Scale bar=5μm)